Interactive Journal of Medical Research

Sarcopenia is defined by age-related reductions in muscle mass, strength, and physiological function, and it is especially prevalent among individuals with autoimmune diseases. Autoimmune disorders, characterized by immune dysregulation, cause systemic inflammation and damage to multiple tissues through unregulated immune activity. Research indicated that autoimmune diseases negatively impact skeletal muscle functions and may worsen the progression of sarcopenia. This viewpoint comprehensively discussed the pathogenesis and potential mechanism of sarcopenia in the three autoimmune diseases, inflammatory bowel disease, rheumatoid arthritis, and Type 1 diabetes mellitus. Mechanistically, chronic immune microenvironment alterations induce compartment-specific redistribution of leukocyte subsets and cytokine networks. These perturbations disrupt critical signaling pathways governing muscle protein synthesis, satellite cell activation, and mitochondrial bioenergetics, leading to impaired regeneration and accelerated sarcopenia progression. By delineating shared and distinct pathomechanisms across these models, this analysis reframes our understanding of immune-mediated muscle wasting. Beyond mechanistic insights, it establishes a translational framework for targeted therapies and highlights emerging research directions bridging immunology and age-related musculoskeletal decline.

Family caregivers commonly help manage medications taken by people living with dementia. Recent work has highlighted the importance of caregiver networks, which are multiple caregivers managing care for a single person with dementia, on managing care for persons living with dementia, especially medication management. However, less is known about the composition of caregiver networks.

The global targets for human immunodeficiency virus (HIV) testing for achieving the United Nations Joint Programme of HIV/AIDS 95–95-95 are still short. Identifying gaps and opportunities for HIV testing uptake is crucial in fast-tracking the second (initiate people living with HIV on antiretroviral therapy) and third (viral suppression) UNAIDS goals. Machine learning and health technologies can precisely predict high-risk individuals and facilitate more effective and efficient HIV testing methods. Despite this advancement, there exists a research gap regarding the extent to which such technologies are integrated into HIV testing strategies worldwide.

Artificial intelligence (AI) is increasingly integrated into palliative medicine, offering opportunities to improve quality, efficiency, and patient-centeredness in end-of-life care. However, its use raises complex ethical issues, including privacy, equity, dehumanization, and decision-making dilemmas.

Urinary incontinence affects approximately 7% to 10% of children during the day and 9% to 12% of children during the night. Treatment mainly involves lifestyle advice and behavioral methods, but motivation and adherence are low. Traditional tools such as pen-and-paper solutions may feel outdated and no longer meet the needs of today’s “digital native” children. Meanwhile, digital interventions have already shown effectiveness in other pediatric health care areas.

Online labor has the potential to change how the healthcare workforce is allocated and managed in healthcare. The contracting, coordination and communication of bookings and work assignment happens on these platforms in near-real time with no delay and without any human interactions on platforms. This perspective paper describes the worldwide trend towards online labor platforms (OLPS) in healthcare, gives an overview about the functioning of these platforms, and discusses the prospects and challenges for healthcare management. As real-world case, the platform logic, growth and traffic of a Swiss online labor platform designed for temporary nurse deployment, are presented. OLPs facilitate managing different work arrangements (float-pools, temporary work) through (1) offering healthcare staff flexible work options which in turn lowers the drop-out rates of healthcare professionals, (2) effectively managing internal allowing human resources sharing within and across healthcare organizations. For healthcare management research, OLPs yield data that can be used to analyze the characteristics, utilization, and dynamics of flexible work arrangements and temporary work in healthcare.

Older adults engage in increased amounts of sedentary behavior (SB), which can result in a significant decline in muscle function and overall health. An understanding of the motivational driving factors that lead older adults to engage in SB can help to create effective intervention programs.

Understanding long-term retention rates and complications associated with different materials for fabricating pediatric crowns for primary teeth is crucial for material selection and optimizing clinical outcomes.

Physical activity and appropriate nutrition are essential for older adults. Improving physical health and quality of life can lead to healthy aging.

Aedes aegypti is an important vector that transmits dengue, Zika, chikungunya, and yellow fever viruses. Although research on Aedes aegypti has been conducted for decades, scientometric studies on Aedes aegypti are scarce, are limited to regions, and cover short periods. Thus, there is still a knowledge gap in the current trend, research focuses and directions, leading authors and collaboration, journal and citation impacts, countries, and worldwide collaborations.

This letter shows that that an estimated 31 million and 44 million adults self-report near daily experiences of depression or anxiety, respectively. Of these, nearly a third have never spoken to a provider about it.

Personality disorders (PDs) are typically associated with higher mental health service use; however, individual patterns of engagement among patients with complex needs are poorly understood.